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Week 6 NFL picks: Best bets, odds for every game

By VSiN Staff  ( 


Welcome to another exciting weekend in the NFL.

With 12 games on Sunday's slate, there are plenty of betting opportunities. Our VSiN experts -- Adam Burke, Wes Reynolds, Dave Tuley, Will Hill and Matt Youmans, along with Ben Brown from Pro Football Focus -- combine to give their opinions on every game.

Note: Lines are from DraftKings Sportsbook as of Thursday night.

Here are our Week 6 best bets:

Miami Dolphins (-3, 45.5) at Jacksonville Jaguars

Tuley: Here we go with another early-morning (9:30 a.m. ET/6:30 a.m. PT) game from London. The Jaguars lost their pre-bye week games in London in 2018 and 2019 (hat tip to Steve Makinen for his pre-bye piece in last week’s Point Spread Weekly), but I’m bucking that trend by taking them here. The Jaguars are far from a good team, but they have shown glimpses of competence and I certainly wouldn’t lay more than a field goal with the Dolphins.

Pick: Jaguars + 3

Houston Texans at Indianapolis Colts (-10, 42.5)

Tuley: Here’s another ugly dog. I mentioned last week how double-digit dogs aren’t faring too well this season, so we have to pick our spots. I was able to resist taking the Dolphins last week against the Buccaneers and felt good about that as they were routed 45-17, but the Texans look like a much more live underdog here, especially considering the competition. Houston nearly upset the Patriots on Sunday before losing 25-22, and don’t forget they covered as 13.5-point

road underdogs in a 31-21 loss to the Browns in Week 2. The Colts were dominating in Baltimore on Monday night before squandering a 22-3 lead and losing 31-25 in OT, but they shouldn’t be laying this many points to any team, especially a divisional rival.

Pick: Texans + 10

Green Bay Packers (-4.5, 45) at Chicago Bears

Brown: Justin Fields is 2-1 as the Bears starting quarterback entering his first start against the Packers. Chicago hasn’t featured a dynamic passing attack with Fields at quarterback, as they have the lowest expected pass rate in neutral situations. The Bears sit 28th in EPA generated per pass play during this three-game stretch. There are still reasons to expect a solid passing performance in Week 6 and it starts with the Packers’ banged-up secondary.

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