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Week 3 NFL picks: Best bets on every game

By VSiN Staff  ( 


Welcome to another exciting weekend in the NFL.

With 14 games on Sunday's slate, there are plenty of betting opportunities. Our VSiN experts -- Adam Burke, Wes Reynolds, Dave Tuley, Jonathan Von Tobel and Matt Youmans, along with Ben Brown from Pro Football Focus -- combine to give their opinions on every game.

Note: Lines are from DraftKings Sportsbook as of Thursday night.

Here are our Week 3 best bets:

Arizona Cardinals (-7.5, 52.5) at Jacksonville Jaguars

Reynolds: The Cardinals have eclipsed the 30-point mark in two consecutive games in their 2-0 start. In fact, quarterback Kyler Murray is now the shortest price at BetMGM for NFL MVP at + 550. Yes, ahead of Patrick Mahomes, Tom Brady, Aaron Rodgers, Russell Wilson, etc. The numbers probably justify the move, as Murray has thrown for 689 yards in two games along with nine combined touchdowns (seven passing, two rushing). Nevertheless, Arizona now takes back to the road in an unfamiliar role as a road favorite of greater than a touchdown. 

Meanwhile, No. 1 overall pick Trevor Lawrence is completing just 50 percent of his passes and has thrown five interceptions in two games. The talent level is still down in Jacksonville, especially on the offensive line. Nevertheless, Arizona is in a dangerous spot here with two NFC West division games (at L.A. Rams, vs. San Francisco) on deck. In the previous five years, 0-2 teams that are home dogs in the third game of the season are 9-4-1 ATS.

Pick: Jaguars + 7.5

Tuley: The top game on Sunday’s betting board features a home underdog of more than a touchdown. These ugly dogs perform very well over the years -- and if an NFL team is getting this many points at home, it’s usually a supposed mismatch like this, but the dogs often cover anyway. So, yes, I’m plugging my nose and taking the Jaguars here.

Lawrence is having his expected growing pains now that he’s on a team whose talent doesn’t tower over the competition like it did when he was at Clemson. He’ll be fine, but the main reason for this bet is that the Cardinals, as exciting as they are with the electric Murray running the show, still have to be more consistent -- and this is the type of game where they often play down to the level of their competition.

Pick: Jaguars + 7.5

Indianapolis Colts at Tennessee Titans (-5.5, 48)

Hill: A desperate, winless team getting over a field goal. That’s the situation the Titans were in last week, as they rallied from a late 14-point deficit against the Seahawks to avoid a disastrous 0-2 start to the season. The Colts find themselves in a similar situation this week, with a comparable spread as well. Indianapolis looks to avoid going 0-3, and may have to rely on Jacob Eason to put it into the win column, as Eason would be making his first career start.

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