Thursday Night Football best bets: 49ers-Titans

By VSiN Staff  ( 

December 23, 2021 09:45 AM

Let's kick off a new week in the NFL with another Thursday Night Football game, this time between the Tennessee Titans and San Francisco 49ers.

We've got a market report on the game from South Point director Chris Andrews and a best bet from Adam Burke as Week 16 gets underway.

San Francisco 49ers (-3.5, 44) at Tennessee Titans

Market Report from Chris Andrews: The 49ers got a lot of market respect the last two weeks vs. Cincinnati and Atlanta. They ashed those tickets, and five of their last six. I opened San Francisco -3.5. Sharps must have thought that was a bit high, since they took the hook with Tennessee. I’m down to San Francisco -3. My opening total of 44.5 hasn’t moved. I see 44’s out there. With so much going on in the sports world right now, this matchup may not draw heavy action until game day. 

Burke: The 49ers drew the short-week travel straw this week and have a long trip from the West Coast to the Music City, but this game is a story of two teams going in opposite directions. The Titans have one win since the middle of November, and it came against the lowly Jacksonville Jaguars right before Urban Meyer was fired. The same Jaguars team that just lost to the Houston Texans this past week.

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