San Francisco 49ers (-3.5,43) at Tennessee Titans
Week 16 begins Thursday night with two teams looking to home in on postseason berths. The 49ers (8-6 SU, 7-7 ATS) are on the road against the reeling Titans (9-5 SU, 8-6 ATS). The Titans held the Steelers to 168 yards of offense last week but turned the ball over four times in defeat, with their only touchdown coming on a short field. The 49ers, once 3-5, have won five of six to put themselves in position to reach the NFC playoffs. They handled the Falcons, gaining more than 7 yards per play in a 31-13 victory.
Cleveland Browns at Green Bay Packers (-7.5, 45)
The short-handed Browns (7-7 SU, 6-8 ATS) suffered a devastating loss Monday night after losing to the Raiders on a last-second field goal. The Browns are now in a must-win situation on a short week as they visit the Packers (11-3 SU and ATS) on Christmas Day. QB Nick Mullens started against the Raiders, but the Browns are hoping for the return of Baker Mayfield and a group of other key players in COVID-19 protocol. The Packers control their destiny for the top seed in the NFC after the Bucs and Cardinals lost last week. At 11-3 against the spread, the Packers are the most profitable team in the league despite not covering last week in Baltimore.
Indianapolis Colts at Arizona Cardinals (-1.5, 49)
The Christmas Day slate concludes with a good one, as the Colts (8-6 SU, 9-5 ATS) visit the Cardinals (10-4 SU, 9-5 ATS). Both teams are likely headed for postseason play but are moving in opposite directions. The Colts were 0-3 in what looked like a lost season but have rallied to win eight of 11. The Cardinals were the last undefeated team but have battled numerous injuries and have lost two in a row and four of six. WR DeAndre Hopkins will miss the rest of the regular season for the Cardinals, who are in danger of dropping out of first place in the NFC West. The Colts will be playing their second straight game on a Saturday, while the Cardinals will be on short rest after losing 30-12 to the Lions on Sunday.
Detroit Lions at Atlanta Falcons (-6, 42)
Winners of two of their last three, the Lions (2-11-1 SU, 9-5 ATS) hit the road to take on the Falcons (6-8 SU and ATS). The Lions not only won as 13-point underdogs against the Cardinals but did so in convincing fashion. They are hoping for the return of RB D’Andre Swift, who hasn’t played since an injury on Thanksgiving. The Falcons were beaten soundly in San Francisco last week and will need to run the table to have any hope of reaching the postseason.
Buffalo Bills at New England Patriots (-2, 43.5)