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Best Monday Night Football bets: Bills-49ers

By VSiN Staff  ( 


The San Francisco 49ers host the Buffalo Bills on Monday Night Football this week, though the game will be played in Glendale, Arizona.

Wes Reynolds and Dave Tuley preview the game and break down their best bets.

Buffalo Bills at San Francisco 49ers (-1, 47)

Reynolds: The Bills (8-3 SU, 6-5 ATS) head west to play in a venue (State Farm Stadium) where they played three weeks ago. The first trip to Glendale, Arizona did not go so well as that was the site of the “Hail Murray” where Kyler Murray found DeAndre Hopkins in the middle of three defenders to hand the Bills a 32-30 loss at the hands of the Arizona Cardinals.

Buffalo needed the bye week after that loss and rebounded with a 27-17 win and cover (-4.5) against the Los Angeles Chargers last Sunday. Nevertheless, the Bills were sloppy in the victory as they committed three turnovers, including two from quarterback Josh Allen (interception, fumble) and were outgained by the Chargers. Now the Bills return to face a potentially resurgent 49ers (5-6 SU, 5-6 ATS) club that may be starting to get over the Super Bowl loss hangover and seems to be getting as healthy as they have been all season.  

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